Care with Terraquant Low-Level Laser System*
Management Solutions using Terraquant
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Mode # 4 is pre-set for Skin and Wound Care Applications. Treatment is
initiated by pressing the button number 4 on the device panel and holding
the emitter at the area of the body. The procedures can be performed once
or twice daily.
The clinical trials reported in this section have sound methodologies, at least a control group and all have been published in peer review scientific journals.
LLLT produced in vitro increases in cell growth of 140200% in mouse-derived fibroblasts, rat-derived osteoblasts and rat-derived skeletal muscle cells, and increased by 155171% growth of normal human epithelial cells. Wound size decreased up to 36% in conjunction with hyperbaric oxygen HBO in ischemic rat models. LLLT produced improvement of greater than 40% in musculoskeletal training injuries, and decreased wound healing time. LLLT reduced by 47% pain of children suffering from oral mucositis.
In vitro, LLLT inhibits bacterial growth of E.coli, Staphylococcus aureus and Pseudomonas aeruginosa.
A randomized double-blind placebo-controlled clinical trial, on thirty consecutive patients with diabetic ulcers or gangrenes and elevated levels of glycosylated hemoglobin, has demonstrated an increase in skin microcirculation due to LLLT, which was an athermic effect, in patients with diabetic microangiopathy. A clinical trial of LLLT, with the combined use of HBO, showed 81% healing of diabetic foot ulcers in patients who previously did not respond to a comprehensive treatment program. The authors conclude that this modality is safe, simple and inexpensive.
clinical trial, studying the efficacy of combined phototherapy with LLLT
in the management of venous ulceration when used in conjunction with standardized
nursing intervention, showed clinical difference in wound healing rate
and a continued reduction in wound size at post-irradiation. A double-blind,
placebo-controlled clinical trial of low energy photon therapy (LEPT)(Red
and Infrared) in venous leg ulcers showed a decrease in ulcer area (compared
to baseline) of 193.0 mm2 in the LEPT group and of 14.7 mm2 in the placebo
A randomized, controlled study examined the effects of infrared and red pulsed monochromatic light with varied pulsations and wavelengths, in addition to standard treatment, on the healing of pressure ulcers. Patients treated with pulsed monochromatic light had a 49% higher ulcer healing rate, their mean ulcer area was reduced to 10% after 5 weeks compared with 9 weeks for the controls.
A controlled clinical trial of patients with two pressure ulcers (one for polarized light, one as control) examined the effect of polarized light on pressure ulcers of 1st, 2nd and 3rd grades. Pressure ulcers subjected to extra treatment with polarized light in the early stages showed significantly greater improvement in the healing process than the control ulcers.
Pulsed high-frequency, high peak power electromagnetic energy has been shown to increased healing time in patients with Stage II ulcers unhealed within three to 12 weeks and those with Stage III ulcers unhealed within eight to 168 weeks by conventional methods. Stage II ulcers healed in one to six weeks (mean 2.33) and all Stage III ulcers healed in one to 22 weeks (mean 8.85).
1. Simunovic Z. Laser Center, Locarno, Switzerland. J Clin Laser Med Surg 1996 Aug;14(4):163-7 Low level laser therapy with trigger points technique: a clinical study on 243 patients.. "LLLT suggests that the laser beam can be used as monotherapy or as a supplementary treatment to other therapeutic procedures for pain treatment". Publication Types: Clinical Trial Controlled Clinical Trial PMID: 9456632 [PubMed - indexed for MEDLINE]
2. Fulga C. N Antiinflammatory effect of laser therapy in rheumatoid arthritis.. Rom J Intern Med 1998 Jul-Dec;36(3-4):273-9
3. Gartner, Laser Therapy, 4:107, 1992.
4. Asada et al, Laser Therapy 3:77, 1991.
5. Moore, in Fontiers in Electro-optics, 283, 1990.
6. Trellis et al, Laser Therapy 3:149, 1991.
7. Lewith GT, Machin D. A randomized trial to evaluate the effect of infra-red stimulation of local trigger points, versus placebo, on the pain caused by cervical osteoarthrosis. Acupunct Electrother Res 1981;6(4):277-84
8. Ozdemir F et al. The clinical efficacy of low power laser therapy on pain and function in cervical osteoarthritis. Clin Rheumatol 2001;20(3): 181-4
9. Ceccherelli F, Diode Laser in cervical myofascial pain: a double-blind study versus placebo. Clin J Pain 1989 Dec;5(4):301-4
10. Ohshiro, in Low-reactive level laser therapy practical application. , 103, Chichester, U.K., John Wiley & Sons, 1991.
11. England S, Farrell AJ, Coppock JS, Struthers G, Bacon PA. Low power laser therapy of shoulder tendonitis. Scand J Rheumatol 1989;18(6):427-31
12. Simunovic Z, Trobonjaca T, Trobonjaca Z. Treatment of medial and lateral epicondylitis--tennis and golfer's elbow--with low level laser therapy: a multicenter double blind, placebo-controlled clinical study on 324 patients. : J Clin Laser Med Surg 1998 Jun;16(3):145-51
13. Arch Phys Med Rehabil 2002 Jul;83(7):978-88 Carpal tunnel syndrome pain treated with low-level laser and microamperes transcutaneous electric nerve stimulation: A controlled study. Naeser MA, Hahn KA, Lieberman BE, Branco KF.
14. Naeser MA, Hahn KA, Lieberman BE, Branco KF. Carpal tunnel syndrome pain treated with low-level laser and microamperes transcutaneous electric nerve. Arch Phys Med Rehabil 2002 Jul;83(7):978-88 stimulation: A controlled study.
15. Kumar et al, Laser in Medical Science, 298, 1988.
16. Gur A et al. Efficacy of low power laser therapy in fibromyalgia: a single-blind, placebo controlled trial. Lasers Med Sci 2002;17(1):57-61
17. Basford JR et al. Laser therapy: a randomized controlled trial of the effects of low intensity laser irradiation on musculoskeletal back pain. Arch Phys Med Rehabili 1999 Jun;80(6):647-52
18. Silva, A.N. et al, J. Clin. Laser Med. Surg. 20:83, 2002.
19. Treller, M.A. and Mayayo, E. Laser Surg. Med. 7:36, 1987
20. Whelan, H.T. et al, J. Clin. Laser Med. Surg. 19:305, 2001.
21. Nussbaum, E.L. et al, Clin. Laser Med. Surg. 20:325, 2002
22. Schindl, A., et al, Low-intensity laser irradiation improves skin circulation in patients with diabetic microangiopathy. Diabetes Care, 21:580, 1998
23. Landau, Z. and Schattner, A. Yale J. Biol. Med. 74:95, 2001
24. Legan, K.M. et al, J. Clin. Laser Med. Surg. 20:109, 2002.
25. Gupta AK, et al. The use of low energy photon therapy (LEPT) in venous leg ulcers: a double-blind, placebo-controlled study.Dermatol Surg 1998 Dec;24(12):1383-6
26. Schubert V. Effects of phototherapy on pressure ulcer healing in elderly patients after a falling trauma. A prospective, randomized, controlled study. Photodermatol Photoimmunol Photomed 2001 Feb;17(1):32-8
27. Lordanou P, et al. Effect of polarized light in the healing process of pressure ulcers. Int J Nurs Pract 2002 Feb;8(1):49-55
28. Itoh M, et al. Accelerated wound healing of pressure ulcers by pulsed high peak power electromagnetic energy (Diapulse). Decubitus
*Wound care indication for Terraquant are intended for use outside of the USA only.